Resveratrol


Resveratrol

Benefits

  • Antioxidant
  • Antibacterial
  • Antiviral
  • Antitumor
  • Immunity
  • Respiratory
  • Liver protection
  • Fatty liver syndrome
  • Neuroprotective
  • Cardioprotective
Resveratrol is a natural polyphenol found in more than 70 plant species. Highest concentrations are found in the skin and seeds of red grapes and Japanese knotweed (polygonum cuspidatum). Resveratrol possesses a wide range of biological properties, among them antioxidant, cardioprotective, neuroprotective, anti-inflammatory and anticancer activities. A summary of research studies about resveratrol conducted specifically in chickens and other poultry are provided in the table below.

Poultry Specific Studies

TypePlant PartDosageSpecific useResultsRef
Broilers200-600 mg/kg of dietHeat stressImproved growth performance and reduced oxidative stress in heat-stressed black-boned chickens by increasing serum growth hormone concentrations and modulating the expression of heat shock genes in organs of the immune system. L Liu et al., 2014
Chicks200-800 mg/kg of dietimmunityimproved growth, protected immunocytes against antigen-induced apoptosis, and upregulated immune response in chickens that received conventional vaccinations.Zhang, CaiYun, et al., 2014
Chickens600 ppm of dietGI healthEnhanced growth performance, improved intestinal morphology, and microbial balance, as well as increased immunity in broiler chickens challenged with E. coli.H Mohebodini et al., 2019
Hens200-400 mg/kg of dietantioxidantSignificantly reduced levels of total serum cholesterol and triglycerides and activities of alanine transaminase and aspartate transaminase.C Zhang et al., 2019
Broilers0.5-1% of dietliver protectionDecreased the severity and degree of the liver lesions in birds ingesting aflatoxins in their feed.M Sridhar et al., 2014
Chickens0.5-4g/kg dietantioxidantHad a positive effect on performance, lipid-related traits and antioxidant activity.Z Feng et al., 2017
Ducks400 mg/kg of dietGI healthincreased the V/C ratio of jejunum and significantly increased the number of goblet cells in jejunum mucosa. Resveratrol activated the SIRT1 signaling pathway, improved the activity of antioxidant enzymes, increased HSPs and tight junction protein mRNA expression upon exposure to acute heat stresses. It further inhibited the NLRP3 inflammasome pathway decreased the secretion of IL-1.C Yang et al., 2021
BroilersImmunityimproved the growth index of thymus, spleen and bursa Fabricius, and increased the serum level of complement C3 of broilers under heat stress. Demonstrated that diets supplementation with resveratrol could inhibited inflammatory response via inhibited NF-B, MAPK, and PI3K/AKT signaling pathways under heat stress condition. Thus, resveratrol may be act as a nutritional regulator to alleviate heat stress-induced high-activated innate immunity and inflammatory response in broilers. S He et al., 2019
BroilersLiver protection, heat stressResveratrol alleviated heat stress-induced liver oxidative damage by enhancing the Nrf2-Keap1 signaling pathway, promoting the growth performance of broilers.K Ding et al., 2022
Broilers350-500 mg/kg of diet for 14 consecutive daysHeat stressimproved average daily gain and decreased rectal temperature from d 3 when compared with heat-stressed group without resveratrol. It also lowered the contents of corticosterone, adrenocorticotropic hormone, cholesterol, triglycerides, uric acid, malonaldehyde, and activities of aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase, increased the levels of triiodothyronine, the ratio of triiodothyronine to thyroxine, total protein, glutathione, and activities of alkaline phosphatase, total superoxide dismutase, catalase, and glutathione peroxidase, though with few fluctuation.S He et al., 2019
Broilers400 mg/kg dietHeat stress, GI healtheffective in partially ameliorating the adverse effects of heat stress on intestinal barrier function in broilers by restoring the impaired villus-crypt structure, modifying the profiles of intestinal microfloras, and altering the mRNA expression of intestinal tight junctions- and adherence junctions-related genes.C Zhang et al., 2017
Broilers500 mg/kg of dietHeat stress, Spleen protectionHad a beneficial effect on white feather broilers' growth performance and anti-inflammatory capacity, suggesting that it might effectively mitigate the deleterious effects of heat stress. RSV could inhibit heat stress-induced activation of splenic NF-B, MAPK, and HSP70, as well as inhibit the activation of mitochondrial apoptotic pathways, thus reducing the splenic inflammatory response in heat-stressed white-feather broilers.T Meng et al., 2022
Broilers400 mg/kg of dietHeat stressimproved broiler’s growth under Heat stress by relieving Heat stress’s adverse effects on intestinal morphology and improving the intestinal mucosa’s antioxidant capacity. The mechanism of action may be related to the activation of the Nrf2 signaling pathway induced by resveratrol.C Wang et al., 2021
Ducks500 mg/kg of dietantioxidant, GI healthimproved the antioxidant capacity of duck ileum by reducing the production of MDA and increasing the activity of T-SOD and CAT. Lipopolysaccharide increased Keap1 at mRNA and protein level and decreased the protein level of Nrf2.H Yang et al., 2021
Hens400 mg/kgliver protectionThe results confirmed that a diet supplemented with resveratrol could protect the liver by regulating the level of cell autophagy. The mRNA expression of Bcl-2 was significantly upregulated and the mRNA level of Caspase-3 was significantly down-regulated in the HELP+Res group compared to the HELP group, which suggested that Res may regulate hepatocyte apoptosis function by modulating the relative mRNA levels of Bcl-2 and Caspase-3.X Wang et al., 2019
Hens600 mg/kg of dietegg productionable to maintain intestinal and ovarian function and mitigate the negative impact of tBHP challenge on production performance and egg quality.X Ding et al., 2022
Hens400 mg/kg of dietliver protection, fatty liver hemorrhagic syndromeeffectively attenuated oxidative stress and inflammation in hens with fatty liver hemorrhagic syndrome and that it could be an effective feed additive to protect hens against the disease. C Xing et al., 2019
Hens400 mg/kg of dietliver protection, fatty liver hemorrhagic syndromeDemonstrated the unique ability of grape pomace and resveratrol to improve physiological traits and gene expression for the prevention of hemorrhagic fatty liver syndrome in laying hens.O Attallah et al., 2022
Quail200-400 mg/kg of dietantioxidantInclusion of resveratrol up to 400 mg/kg into quail diets enhanced antioxidant status of birds and eggs. K Sahin et al., 2010

References