Grape Seed Extract

Grape seed extract

Grape seed extract


  • Antibacterial
  • Antioxidant
  • Anticonvulsant
  • Antifungal
  • Anticoccidial
  • Hepatoprotective
  • Wound-healing
  • Kidney-protection
  • Immunity
  • Neuroprotective
Grape seed extract (GSE) is a potent antioxidant which is made from the seeds of grapes. It is also one of the best-known sources of proanthocyanidins. Its high antioxidant content is well-known for its benefits associated with disease prevention and protection against oxidative stress, tissue damage, and inflammation. GSE also inhibits the growth of Campylobacter, E. coli, Staphylococcus aureus bacteria and Candida fungi.

Research conducted on the addition of GSE to the diet of chickens have showed positive results for it’s use as a potent antioxidant and immune enhancer when supplemented to their diet. Farahat, M. H., et al., 2017 recommended adding it at a rate of 125 to 250 ppm as the optimum dosage. 250-500 mg/kg showed protective effects against liver damage caused by aflatoxicosis (S Rajput et al., 2018). 12 mg/kg was beneficial for chickens with coccidiosis (Wang, M. L., et al., 2008).

Poultry Specific Studies

TypePlant PartDosageSpecific useResultsRef
Chickensextract12 mg/kg of dietanticoccidialImproved the clinical symptoms associated with oxidative stress caused by coccidiosis.Wang, M. L., et al., 2008
Broilersup to 3.6 g/kg of dietantioxidantSignificantly increased antioxidant activity in diet and excreta.J Carrasco et al., 2016
Chickens125-250 ppm of dietantioxidantconsidered the optimum dosage to add to the daily diet of chickens as a natural antioxidant and immune enhancer Farahat, M. H., et al., 2017
Chickens250-500 mg/kg dietantioxidant, aflatoxicosishas protective effects against aflatoxicosis caused by aflatoxins in poultry feed.S Rajput et al., 2018
Hens5 g/mL dietantioxidantReduced antioxidant capacity decline by increasing the antioxidase activities and their gene expression in either D-gal-induced or natural aging ovaries. Moreover, GSPE could maintain the homeostasis between cell proliferation and apoptosis in the D-gal-induced and natural aging ovaries, as well as alleviate D-gal-induced nucleus chromatin condensation in the ovarian granulosa cells. In conclusion, GSPE treatment can effectively prevent the ovarian aging process in hens by reducing oxidative stress.X Liu et al., 2018
Hens1% dietreproductive, offspring viabilityincreased offspring viability and reduced oxidative stress suggesting a beneficial transgenerational effect and a potential use to improve the quality of the progeny in reproductive hens.A Barbe et al., 2020
Ducks0.01-0.02% dietantioxidantPartially improved antioxidant activities, immunity and gut health.X Ao et al., 2020
Chickens75 mg/kg dietanticoccidialGrape seed proanthocyanidin extract diminishes coccidiosis via the downregulation of oxidative stress (strong antioxidant). Damages the morphology of oocysts in terms of shape, size and number of sporocysts. Shows antioxidant activity. Improves gut pathology, and body weight gain.N El-Shall et al., 2022