• Antiviral
  • Anti-inflammatory
  • Antibacterial
  • Antidiabetes
  • Antioxidant
  • Antihelmintic
  • Antitumor
  • Immunity
  • Hepatoprotective
Genistein is a polyphenolic isoflavone originally found in the Genista tinctoria plant which it was named after. Natural sources of genistein include tofu, fava beans, soybeans, kudzu, and lupin. It is a phytoestrogen that is a naturally occurring chemical constituent with a similar chemical structure to mammalian estrogens.

In humans, genistein has shown beneficial effects for protection against osteoporosis, reduction in the risk of cardiovascular disease, alleviation of postmenopausal symptoms and anticancer properties. It also has anti-inflammatory properties. It is currently being studied in clinical trials as a treatment for prostate cancer. Unfortunately, Genistein is limited in its bioavailability after oral administration due to its poor water solubility.

Poultry Specific Studies

TypePlant PartDosageSpecific useResultsRef
Chicks20 mg/kg dietimmunityWhen combined with hesperidin it improved the immunity and the morphometry of the small intestine of baby chicks in a dose-dependent manner.A Kamboh et al., 2014
Chicks20-80 mg/kg of dietimmunityCBH response and antibody titers against Newcastle and infectious bronchitis disease viruses were markedly greater in chicks fed on diets supplemented with 20 to 80 mg/kg of genistein. Dietary inclusion of genistein increased lymphocytes and subsequently reduced heterophil to lymphocyte ratio. E Rasouli et al., 2015
Chicksmetabolism disordersimproved glucose metabolism via activating the GPER-mediated cAMP/PKA-AMPK signaling pathway.Q Li et al., 2022
Chicks40 mg/kg of dietGI healthimproved intestinal morphology, mucosal immune function, tight junction, antioxidant activity, apoptotic process, and growth performance, which were adversely damaged by LPS injection.Z Lv et al., 2020
Chicks40 mg/kg dietimmunityaltered the RNA expression profile and AS signatures in the thymus and alleviated immune response against lipopolysaccharide challenge.Z Huang et al., 2021
Broilers5-20 mg/kg of dietheat stressHelped ameliorate summer stress effects in broilers. Decreased circulating heterophils and heterophil-to-lymphocyte ratios.A Kamboh et al., 2013
Hens40-400 mg/kg of dietantioxidantcan alter lipid metabolism in the offspring chicks through epigenetic modification and improve the antioxidative capability as well as growth performance.Z Lv et al., 2019
Hens40-400 mg/kg of dietliver protection, fatty liver syndromeDietary GEN alleviated metabolic disorder and inflammation in the FLS hens by improving the antioxidant capacity and fatty acid profile.Z Lv et al., 2018
Hens120 mg/kg of dietegg qualityimproved the laying rate, eggshell quality, and antioxidant capacity in Hy-Line brown hens during the late laying period.Z E et al., 2023
Hens3-106 mg/hen/dayantitumor, ovarian cancerdemonstrated the preventive effects and mechanisms of genistein in the laying hen model that develops spontaneous ovarian cancer at high incidence rates. Genistein supplementation significantly reduced the ovarian tumor incidence (P = 0.002), as well as the number and size of the tumors (P = 0.0001).K Sahin et al., 2019
Hens40 mg/kg of dietliver protection, fatty liver diseasealleviated metabolic disorder and inflammation induced by the high-energy and low-protein diet given to laying hens.X Gao et al., 2021
Hens40-400 mg/kg of dietbone strength, egg qualitycould improve the egg production and quality, as well as the bone status of LBB hens during the late egg-laying period.Z Lv et al., 2019