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Brand Names:
Vfend
Drug Type:
Antifungal
Voriconazole
Overview
Voriconazole (brand name Vfend®) is a second-generation triazole antifungal medication. It is used to treat serious fungal infections, such as advanced cases of candidiasis and
aspergillosis
.
Dosage
Chickens: 10 mg/kg given orally, every 12 hours
Ducks: 20 mg/kg PO, IV q8-12h
Drug Interactions
Acetylsalicylic acid:The metabolism of Acetylsalicylic acid can be decreased when combined with Voriconazole.
Albendazole: The metabolism of Albendazole can be decreased when combined with Voriconazole.
Amphotericin B: The therapeutic efficacy of Amphotericin B can be decreased when used in combination with Voriconazole.
Betamethasone: The serum concentration of Betamethasone can be increased when it is combined with Voriconazole.
Buprenorphine:The metabolism of Buprenorphine can be decreased when combined with Voriconazole.
Celecoxib:The metabolism of Celecoxib can be decreased when combined with Voriconazole.
Cephalexin: The metabolism of Cephalexin can be decreased when combined with Voriconazole.
Chloramphenicol:The serum concentration of Voriconazole can be increased when it is combined with Chloramphenicol.
Chloroquine: The metabolism of Chloroquine can be decreased when combined with Voriconazole.
Chlorpromazine: The metabolism of Chlorpromazine can be decreased when combined with Voriconazole.
Clindamycin:The metabolism of Clindamycin can be decreased when combined with Voriconazole.
Clotrimazole: The metabolism of Voriconazole can be decreased when combined with Clotrimazole.
Dexamethasone:The metabolism of Dexamethasone can be decreased when combined with Voriconazole.
Diazepam:The metabolism of Diazepam can be decreased when combined with Voriconazole.
Diclofenac: The metabolism of Diclofenac can be decreased when combined with Voriconazole.
Dicoumarol:The serum concentration of Dicoumarol can be increased when it is combined with Voriconazole.
Doxycycline:The metabolism of Voriconazole can be decreased when combined with Doxycycline.
Enalapril:The metabolism of Enalapril can be decreased when combined with Voriconazole.
Erythromycin:The metabolism of Erythromycin can be decreased when combined with Voriconazole.
Estradiol:The metabolism of Estradiol can be decreased when combined with Voriconazole.
Fluocinolone Acetonide:The serum concentration of Fluocinolone Acetonide can be increased when it is combined with Voriconazole.
Ivermectin: The metabolism of Ivermectin can be decreased when combined with Voriconazole.
Ketoprofen: The metabolism of Ketoprofen can be decreased when combined with Voriconazole.
Ketoconazole: The metabolism of Ketoconazole can be decreased when combined with Voriconazole.
Leuprolide:Voriconazole may increase the QTc-prolonging activities of Leuprolide.
Levonorgestrel:The serum concentration of Levonorgestrel can be increased when it is combined with Voriconazole.
Magnesium Sulfate:The risk or severity of adverse effects can be increased when Voriconazole is combined with Magnesium Sulfate.
Mebendazole:The metabolism of Mebendazole can be decreased when combined with Voriconazole.
Medroxyprogesterone acetate: The serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Voriconazole.
Melatonin:The metabolism of Melatonin can be decreased when combined with Voriconazole.
Meloxicam:The serum concentration of Meloxicam can be increased when it is combined with Voriconazole.
Miconazole:The metabolism of Miconazole can be decreased when combined with Voriconazole.
References
Speer, Brian
Current therapy in avian medicine and surgery
.
Elsevier Health Sciences
(2015)
Beernaert, L. A., et al..
Aspergillus infections in birds: a review
Avian Pathology 39.5
(2010)
Burhenne, Jürgen, et al..
Pharmacokinetics, tissue concentrations, and safety of the antifungal agent voriconazole in chickens
Journal of avian medicine and surgery 22.3
(2008)
Burhenne, Jürgen, et al.
Pharmacokinetics, tissue concentrations, and safety of the antifungal agent voriconazole in chickens
Journal of avian medicine and surgery 22.3
(2008)
Scope, A., et al
Pharmacokinetics and pharmacodynamics of the new antifungal agent voriconazole in birds
.
Proc Eur Assoc Avian Vet
(2005)
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