Brand Names:
Marquis, Ponalrestat

Drug Type: Antiprotozoal


Ponazuril is an anti-protozoal drug used to treat Toxoplasmosis (caused by the protozoa, Toxoplasma gondii), Coccidiosis (caused by Eimeria species), and Sarcocystosis (caused by Sarcocystis protozoa). Ponazuril is also referred to as toltrazuril sulfone. It is manufactured under the brand names Marquis and Ponalrestat.

Marquis is supplied as a paste which is marketed for treatment equine protozoal myeloencephalitis (EPM) in horses caused by the protozoa Sarcocystis neurona. It can however, also be given to pet poultry if the paste is diluted properly. One tube of Marquis paste contains 127 grams (4.5 oz) at 150 mg/gm (19,050 mgs total per tube) which is a 15% solution. Marquis paste is reportedly stable in suspension and can be mixed with water and VAL syrup or other suspensions to improve palatability and dilute the drug concentration.

Marquis Paste Dilution Instructions:
50 mls Marquis paste + 12.5 mls water + 12.5 mls syrup for flavor = 75 mls of 100 mg/ml solution.

Or for a smaller amount at one time:

20 mls Marquis paste + 5 mls water + 5 mls syrup for flavor = 30 mls of 100 mg/ml solution.

Storage Recommendations
The diluted paste solution should be kept refrigerated, in a UV-light proof container prior to use. Shake thoroughly prior to administering the product.
  • 10-20 mg/kg administered orally, once a day for 3 to 5 days (coccidiosis), or once a day for a month (sarcocystosis or toxoplasmosis)
  • Diarrhea