Brand Names:

Drug Type: Antibiotic

Penicillin G

Penicillin G is a natural penicillin and is available in several different salt forms. Natural penicillins remain the drugs of choice for a variety of bacteria, including group A beta-hemolytic streptococci, many gram positive anaerobes, spiro­chetes, gram negative aerobic cocci, and some gram negative aerobic bacilli. Generally, if a bacteria is susceptible to a natural penicillin, either penicillin G or V is preferred for treating that infection as long as adequate penetration of the drug to the site of the infec­tion occurs and the patient is not hypersensitive to penicillins.

Penicillin is mainly of benefit only for cases where birds are infected with Pasteurella spp. and some gram-positive organisms. Pasteurella spp. are commonly found in the oral cavity of dogs, cats and other canine and feline predators.

Storage/Stability: Penicillin G sodium and potassium should be protected from moisture to prevent hydrolysis of the compounds. Penicillin G potassium tablets and powder for oral solution should be stored at room temperature in tight containers; avoid exposure to excessive heat. After reconstituting, the oral powder for solution should be stored from 2-8°C (refrigerated) and discarded after 14 days. Penicillin G sodium and potassium powder for injection can be stored at room tempera­ture (15-30°C). After reconstituting, the injectable solution is stable for 7 days when kept refrigerated (2-8°C) and for 24 hours at room temperature. Penicillin G procaine should be stored at 2-8°C; avoid freezing. Benzathine penicillin G should be stored at 2-8°C.
  • For chickens, 1/2 to 3 cc PO for 3-5 days
  • Hypersensitivity
  • Will decrease potassium levels in the blood (hypokalemia)
  • Amphotericin B : Renal damage and hypokalemia