Brand Names:
Catenulin, Aminosidine, Humatin


Drug Type: Antibiotic

Paromomycin

Paromomycin is a broad-spectrum aminoglycoside antibiotic which is used to treat intestinal parasitic infections involving protozoa. The in vitro and in vivo antibacterial action of paromomycin closely parallels that of neomycin.

Paromomycin has been used in the treatment of Cryptosporidium, Giardia and Histomonas meleagridis infections in birds.

Aminoglycoside antibiotics are toxic to the kidneys and therefore should be used with caution, especially in birds with renal disease.
  • 100 mg/kg given orally every 12 hours for 5-7 days
  • Kidney damage
  • Hearing damage
  • Acetylsalicylic acid:The risk or severity of nephrotoxicity can be increased when Acetylsalicylic acid is combined with Paromomycin.
  • Amikacin:Paromomycin may decrease the excretion rate of Amikacin which could result in a higher serum level.
  • Amoxicillin:The serum concentration of Paromomycin can be decreased when it is combined with Amoxicillin.
  • Ampicillin: The serum concentration of Paromomycin can be decreased when it is combined with Ampicillin.
  • Apramycin: The risk or severity of nephrotoxicity can be increased when Paromomycin is combined with Apramycin.
  • Bacitracin:The risk or severity of nephrotoxicity can be increased when Bacitracin is combined with Paromomycin.
  • Carprofen: The risk or severity of nephrotoxicity can be increased when Carprofen is combined with Paromomycin.
  • Cefadroxil:The risk or severity of nephrotoxicity can be increased when Cefadroxil is combined with Paromomycin.
  • Cefalotin: The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Paromomycin.
  • Cefapirin: The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Paromomycin.
  • Cefpodoxime: The risk or severity of nephrotoxicity can be increased when Cefpodoxime is combined with Paromomycin.
  • The risk or severity of nephrotoxicity can be increased when Cefpodoxime is combined with Paromomycin: The risk or severity of nephrotoxicity can be increased when Cephalexin is combined with Paromomycin.
  • Clindamycin: The risk or severity of neuromuscular blockade can be increased when Clindamycin is combined with Paromomycin.
  • Clove oil:Paromomycin may decrease the excretion rate of Clove oil which could result in a higher serum level.
  • Cloxacillin: The serum concentration of Paromomycin can be decreased when it is combined with Cloxacillin.
  • Dextran: Paromomycin may decrease the excretion rate of Dextran which could result in a higher serum level.
  • Diazepam: Paromomycin may decrease the excretion rate of Diazepam which could result in a higher serum level.
  • Doxycycline:The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Paromomycin.
  • Folic acid: Paromomycin may decrease the excretion rate of Folic acid which could result in a higher serum level.
  • Furosemide: Furosemide may increase the ototoxic activities of Paromomycin.
  • Gentamicin: Paromomycin may decrease the excretion rate of Gentamicin which could result in a higher serum level.
  • Lidocaine:The risk or severity of methemoglobinemia can be increased when Paromomycin is combined with Lidocaine.
  • Lincomycin: The risk or severity of neuromuscular blockade can be increased when Paromomycin is combined with Lincomycin.
  • Magnesium sulfate: The risk or severity of neuromuscular blockade can be increased when Magnesium sulfate is combined with Paromomycin.
  • Meloxicam: The risk or severity of methemoglobinemia can be increased when Paromomycin is combined with Meloxicam.
  • Neomycin: The risk or severity of nephrotoxicity can be increased when Paromomycin is combined with Neomycin.
  • Oxytetracycline: The risk or severity of neuromuscular blockade can be increased when Oxytetracycline is combined with Paromomycin.
  • Pentobarbital: Paromomycin may decrease the excretion rate of Pentobarbital which could result in a higher serum level.
  • Prednisone: Paromomycin may decrease the excretion rate of Prednisone which could result in a higher serum level.
  • Pyrantel: The therapeutic efficacy of Pyrantel can be increased when used in combination with Paromomycin.
  • Pyridoxine:Paromomycin may decrease the excretion rate of Pyridoxine which could result in a higher serum level.
  • Selenium: Paromomycin may decrease the excretion rate of Selenium which could result in a higher serum level.
  • Sulfadiazine: Paromomycin may decrease the excretion rate of Sulfadiazine which could result in a higher serum level.

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