Itraconazole is an antifungal drug used for treating aspergillosis, sour crop (candida), histoplasmosis, and cryptococcus. It is often used in combination with other drugs, such as amphotericin B and/or clotrimazole. Itraconazole is more effective against Aspergillus spp. than other antifungal drugs, and has less potential toxic side effects.
Itraconazole absorption is highly dependent on gastric pH and presence of food. When given on an empty stomach bioavailability may only be 50% or less, with food it may approach 100%.
