Brand Names:

Drug Type: Antifungal


Itraconazole is an antifungal drug used for treating aspergillosis, sour crop (candida), histoplasmosis, and cryptococcus. It is often used in combination with other drugs, such as amphotericin B and/or clotrimazole. Itraconazole is more effective against Aspergillus spp. than other antifungal drugs, and has less potential toxic side effects.

Itraconazole absorption is highly dependent on gastric pH and presence of food. When given on an empty stomach bioavailability may only be 50% or less, with food it may approach 100%.
  • Orally: 5-10 mg/kg q12-24h
  • Reduced appetite
  • Yellowing of the eyes or skin
  • Cough up mucus
  • fast, irregular heartbeat
  • meloxicam
  • certain antibiotics like ciprofloxacin, clarithromycin, erythromycin
  • certain medicines for the heart like disopyramide, dofetilide, dronedarone, eplerenone, quinidine, ranolazine
  • colchicine
  • other medicines that prolong the QT interval (cause an abnormal heart rhythm)
  • red yeast rice
  • certain medicines for seizures like carbamazepine, phenytoin
  • other medicines for fungal infections
  • praziquantel