Amikacin is a semi-synthetic aminoglycoside antibiotic used primarily for the treatment of infections caused by aerobic gram-negative organisms. It is not active against anaerobic organisms. It is active against
Pseudomonas spp., especially when combined with a third generation cephalosporin (cefotaxime) or late generation penicillin (piperacillin).
Amikacin is not useful for birds with abscesses and exudates.
Absorption: Amikacin is rapidly and well absorbed from intramuscular (IM) and subcutaneous (SC) routes of administration. It is poorly absorbed from oral administration in adult birds. IM injections may cause myositis.
Notes
- Amikacin should be used in caution in birds with kidney disease. It is the least nephrotoxic of the aminoglycosides (others include gentamicin, neomycin, and dihydrostreptomycin). To minimize risk of renal failure, ensure the bird stays hydrated while on this drug.
- Aminoglycosides should be used with caution in birds with neuromuscular disorders. Ototoxicity of the aminoglycosides can be manifested by either auditory and/or vestibular symptoms and may be irreversible.
- May cause neuromuscular blockade, facial edema, pain/inflammation at injection site, peripheral neuropathy and hypersensitivity reactions.
- Rarely, GI symptoms, hematologic and hepatic effects have been reported in birds receiving amikacin.
- Uric acid levels may be abnormal for up to 7 days after cessation.
- 1.3 grams of amikacin sulfate is equivalent to 1 gram of amikacin.
Storage/Stability: Amikacin is stable for at least 2 years at room temperature.
Disclaimer: Use at your own risk. We assume no responsibility for the use of the drug, dosages given and for any misstatement, error, negligent, or otherwise.
