Grape seed extract (GSE) is a potent antioxidant which is made from the seeds of grapes. It is also one of the best-known sources of proanthocyanidins. Its high antioxidant content is well-known for its benefits associated with disease prevention and protection against oxidative stress, tissue damage, and inflammation. GSE also inhibits the growth of Campylobacter, E. coli, Staphylococcus aureus bacteria and Candida fungi.
Research conducted on the addition of GSE to the diet of chickens have showed positive results for it’s use as a potent antioxidant and immune enhancer when supplemented to their diet. Farahat, M. H., et al., 2017 recommended adding it at a rate of 125 to 250 ppm as the optimum dosage. 250-500 mg/kg showed protective effects against liver damage caused by aflatoxicosis (S Rajput et al., 2018). 12 mg/kg was beneficial for chickens with coccidiosis (Wang, M. L., et al., 2008).
Poultry Specific Studies
| Type | Plant Part | Dosage | Specific use | Results | Ref |
|---|
| Chickens | extract | 12 mg/kg of diet | anticoccidial | Improved the clinical symptoms associated with oxidative stress caused by coccidiosis. | Wang, M. L., et al., 2008 |
| Broilers | | up to 3.6 g/kg of diet | antioxidant | Significantly increased antioxidant activity in diet and excreta. | J Carrasco et al., 2016 |
| Chickens | | 125-250 ppm of diet | antioxidant | considered the optimum dosage to add to the daily diet of chickens as a natural antioxidant and immune enhancer | Farahat, M. H., et al., 2017 |
| Chickens | | 250-500 mg/kg diet | antioxidant, aflatoxicosis | has protective effects against aflatoxicosis caused by aflatoxins in poultry feed. | S Rajput et al., 2018 |
| Hens | | 5 g/mL diet | antioxidant | Reduced antioxidant capacity decline by increasing the antioxidase activities and their gene expression in either D-gal-induced or natural aging ovaries. Moreover, GSPE could maintain the homeostasis between cell proliferation and apoptosis in the D-gal-induced and natural aging ovaries, as well as alleviate D-gal-induced nucleus chromatin condensation in the ovarian granulosa cells. In conclusion, GSPE treatment can effectively prevent the ovarian aging process in hens by reducing oxidative stress. | X Liu et al., 2018 |
| Hens | | 1% diet | reproductive, offspring viability | increased offspring viability and reduced oxidative stress suggesting a beneficial transgenerational effect and a potential use to improve the quality of the progeny in reproductive hens. | A Barbe et al., 2020 |
| Ducks | | 0.01-0.02% diet | antioxidant | Partially improved antioxidant activities, immunity and gut health. | X Ao et al., 2020 |
| Chickens | | 75 mg/kg diet | anticoccidial | Grape seed proanthocyanidin extract diminishes coccidiosis via the downregulation of oxidative stress (strong antioxidant). Damages the morphology of oocysts in terms of shape, size and number of sporocysts. Shows antioxidant activity. Improves gut pathology, and body weight gain. | N El-Shall et al., 2022 |
References
- Grandhaye, Jérémy, et al. "Maternal dietary supplementation with grape seed extract in reproductive hens increases fertility in females but decreases semen quality in males of the F1 generation" PloS one 16. (2021)
- Barbe, Alix, et al. "A grape seed extract maternal dietary supplementation improves egg quality and reduces ovarian steroidogenesis without affecting fertility parameters in reproductive hens" PLoS One 15.5 (2020)
- Barbe, Alix, et al. "A grape seed extract maternal dietary supplementation in reproductive hens reduces oxidative stress associated to modulation of plasma and tissue adipokines expression and improves viability of offsprings" PLoS One 15.4 (2020)
- Grandhaye, Jeremy, et al.. "Microbiota Changes Due to Grape Seed Extract Diet Improved Intestinal Homeostasis and Decreased Fatness in Parental Broiler Hens" Microorganisms 8.8 (2020)
- Liu, Xingting, et al. "Grape seed proanthocyanidin extract prevents ovarian aging by inhibiting oxidative stress in the hens" Oxidative Medicine and Cellular Longevity (2018)
- Sun, Peipei, et al. "The effect of grape seed extract and yeast culture on both cholesterol content of egg yolk and performance of laying hens" Journal of Applied Poultry Research 27.4 (2018)
- Kara, Kanber, et al. "Effects of grape pomace supplementation to laying hen diet on performance, egg quality, egg lipid peroxidation and some biochemical parameters" Journal of Applied Animal Research 44.1 (2016)
