Novobiocin sodium is an aminocoumarin antibiotic. The spectrum of activity of novobiocin includes some gram positive cocci (Staphs, Streptococcus pneumonia, and some group A streps). Activity is variable against other Streptococci and weak against the Enterococci. Most gram negative organisms are resistant to the drug, but some Haemophilus sp., Neisseria sp., and Proteus sp. may be susceptible. After oral administration, novobiocin is well absorbed from the GI tract. Peak levels occur within 1-4 hours. The presence of food can decrease peak concentrations of the drug.
Storage/Stability: Novobiocin should be stored in tight containers and at room temperature unless otherwise directed.
